(S)-(+)-2-(Methoxymethyl)pyrrolidine → HCID 59170025, compound

HRID 1446222Notes

Reaction equation

HRID 1446222 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH3:16][O:17][CH2:18][C@@H:19]1[CH2:23][CH2:22][CH2:21][NH:20]1>>[CH3:16][O:17][CH2:18][C@@H:19]1[CH2:23][CH2:22][CH2:21][N:20]1[C:13]([C:9]1[CH:10]=[N:11][O:12][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=1)=[O:15]

Participants

3

Reactant 2

HCID 671217(S)-(+)-2-(Methoxymethyl)pyrrolidineHCID 228317065-(p-Tolyl)isoxazole-4-carboxylic acid

Product 1

HCID 59170025HCID 59170025, compound

Procedure

The title compound was prepared from 5-(4-methylphenyl)isoxazole-4-carboxylic acid (10.2 mg, 0.050 mmol) and (S)-2-methoxymethyl-pyrrolidine (6.9 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (4.6 mg). Calcd for C17H20N2O3: 300.1474, found 300.1474.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-edd219ff1f524da7bdac3dd762354cda
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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