HCID 17749748, compound → HCID 59170211, compound

HRID 1446224Notes

Reaction equation

HRID 1446224 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.C(O)(=O)C(O)=O.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([CH:29]2[CH2:33][CH2:32][NH:31][CH2:30]2)=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:31]1[CH2:32][CH2:33][CH:29]([C:26]2[CH:27]=[CH:28][C:23]([Cl:22])=[CH:24][CH:25]=2)[CH2:30]1)=[O:15]

Participants

3

Reactant 2

HCID 17749748HCID 17749748, compoundHCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 59170211HCID 59170211, compound

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 3-(4-chlorophenyl)pyrrolidine oxalate (16.3 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (2.5 mg). Calcd for C20H16Cl2 N2O2: 386.0589, found 386.0595.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-cc9b328b6a314ef8a9ed3075dd828271
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

Loading…