5-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid → 5-(2-Chlorophenyl)-4-({3-[4-(trifluoromethyl)phenyl]pyrrolidin-1-yl}carbonyl)isoxazole

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Reaction Steps

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 3-[4-(trifluoromethyl)phenyl]pyrrolidine oxalate (15.1 mg, 0.050 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (3.8 mg). Calcd for C21H16ClF3N2O2: 420.0852, found 420.0855.

Provenance & Evidence