HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Methoxybenzyl)pyrrolidine oxalate → 5-(2-Chlorophenyl)-4-{[3-(4-methoxybenzyl)pyrrolidin-1-yl]carbonyl}isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Methoxybenzyl)pyrrolidine oxalate | HCID 17998817 | — |
| Reactant | 5-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid | HCID 22494276 | — |
| Product | 5-(2-Chlorophenyl)-4-{[3-(4-methoxybenzyl)pyrrolidin-1-yl]carbonyl}isoxazole | HCID 59170127 | — |
Reaction Steps
The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 3-(4-methoxybenzyl)pyrrolidine oxalate (16.9 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (8.1 mg). Calcd for C22H21ClN2O3: 396.1241, found 396.1235.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-995b8bf3cd7749bf80e9d6ba1d04fe3f |
| Source note | uspto-grants-2010_02 |