HCID 17749758, compound → HCID 59170046, compound

HRID 1446239Notes

Reaction equation

HRID 1446239 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.Cl.Cl.Cl.[NH:19]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[N:28][CH:27]=[CH:26][N:25]=2)[CH2:20]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:19]1[CH2:23][CH2:22][CH:21]([C:24]2[CH:29]=[N:28][CH:27]=[CH:26][N:25]=2)[CH2:20]1)=[O:15]

Participants

3

Reactant 2

HCID 17749758HCID 17749758, compoundHCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 59170046HCID 59170046, compound

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 2-pyrrolidin-3-yl-pyrazine trihydrochloride (15.5 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (7.0 mg). Calcd for C18H15ClN4O2: 354.0884, found 354.0885.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-9236d39e404c4d8a84e9abb24f7f9b9c
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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