5-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid → HCID 59170026, compound

HRID 1446240Notes

Reaction equation

HRID 1446240 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.Cl.[C:17]1([S:23]([CH:26]2[CH2:30][CH2:29][NH:28][CH2:27]2)(=[O:25])=[O:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:28]1[CH2:29][CH2:30][CH:26]([S:23]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)(=[O:25])=[O:24])[CH2:27]1)=[O:15]

Participants

3

Reactant 2

HCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acidHCID 441187183-(Phenylsulfonyl)pyrrolidine hydrochloride

Product 1

HCID 59170026HCID 59170026, compound

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 3-(benzenesulfonyl)pyrrolidine hydrochloride (12.7 mg, 0.051 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (13.5 mg). Calcd for C20H17ClN2O4 S: 416.0598, found 416.0591.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-a51ed26656604f4b828641c8d48eb079
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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