HCID 17749891, compound → HCID 59170175, compound

HRID 1446241Notes

Reaction equation

HRID 1446241 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.Cl.[CH3:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([CH:27]2[CH2:31][CH2:30][NH:29][CH2:28]2)(=[O:26])=[O:25])=[CH:20][CH:19]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:29]1[CH2:30][CH2:31][CH:27]([S:24]([C:21]2[CH:22]=[CH:23][C:18]([CH3:17])=[CH:19][CH:20]=2)(=[O:26])=[O:25])[CH2:28]1)=[O:15]

Participants

3

Reactant 2

HCID 17749891HCID 17749891, compoundHCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 59170175HCID 59170175, compound

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 3-(4-methylphenylsulfonyl)pyrrolidine hydrochloride (15.7 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (13.3 mg). Calcd for C21H19ClN2O4 S: 430.0754, found 430.0753.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-7dbcb53efd634e3db515e52761d28c46
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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