3,5-Dimethylpiperidine → HCID 59170047, compound

HRID 1446243Notes

Reaction equation

HRID 1446243 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.[CH3:16][CH:17]1[CH2:22][CH:21]([CH3:23])[CH2:20][NH:19][CH2:18]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:19]1[CH2:20][CH:21]([CH3:23])[CH2:22][CH:17]([CH3:16])[CH2:18]1)=[O:15]

Participants

3

Reactant 2

HCID 1182593,5-DimethylpiperidineHCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 59170047HCID 59170047, compound

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and 3,5-dimethylpiperidine (6.8 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (2.1 mg). Calcd for C17H19ClN2O2: 318.1135, found 318.1136.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-3302dc3143634ca48f58eebbdd5da8e5
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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