5-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid → HCID 59170216, compound

HRID 1446245Notes

Reaction equation

HRID 1446245 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.[CH3:16][C:17]([CH3:25])([CH:19]1[CH2:24][CH2:23][CH2:22][NH:21][CH2:20]1)[OH:18]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:21]1[CH2:22][CH2:23][CH2:24][CH:19]([C:17]([OH:18])([CH3:25])[CH3:16])[CH2:20]1)=[O:15]

Participants

3

Reactant 2

HCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acidHCID 451571082-(3-Piperidinyl)-2-propanol

Product 1

HCID 59170216HCID 59170216, compound

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and dimethyl-3-piperidylmethanol (10.8 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (5.7 mg). Calcd for C18H21ClN2O3: 348.1241, found 348.1236.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-418f024489aa463a81e4aae11405c93c
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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