(S)-(+)-2-(Methoxymethyl)pyrrolidine → HCID 59170242, compound

HRID 1446246Notes

Reaction equation

HRID 1446246 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([OH:15])=O.[CH3:16][O:17][CH2:18][C@@H:19]1[CH2:23][CH2:22][CH2:21][NH:20]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:12][N:11]=[CH:10][C:9]=1[C:13]([N:20]1[CH2:21][CH2:22][CH2:23][C@H:19]1[CH2:18][O:17][CH3:16])=[O:15]

Participants

3

Reactant 2

HCID 671217(S)-(+)-2-(Methoxymethyl)pyrrolidineHCID 224942765-(2-Chlorophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 59170242HCID 59170242, compound

Procedure

The title compound was prepared from 5-(2-chlorophenyl)isoxazole-4-carboxylic acid (11.2 mg, 0.050 mmol) and (S)-2-methoxymethyl-pyrrolidine (6.9 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (11.9 mg). Calcd for C16H17ClN2O3: 320.0928, found 320.0932.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-cfadb5bfdfd34b0dbd8e776b2b7e8626
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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