HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzylpyrrolidine → 4-[(2-Benzylpyrrolidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzylpyrrolidine | HCID 339556 | — |
| Reactant | 4-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]- | HCID 68682921 | — |
| Product | 4-[(2-Benzylpyrrolidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]isoxazole | HCID 59170051 | — |
Reaction Steps
The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and 2-benzylpyrrolidine (9.7 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (12.5 mg). Calcd for C22H19F3N2O2: 400.1399, found 400.1398.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-28dd43e75af04880b418e7ec668ea0b6 |
| Source note | uspto-grants-2010_02 |