HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Chlorobenzyl)pyrrolidine oxalate → 4-{[3-(2-Chlorobenzyl)pyrrolidin-1-yl]carbonyl}-5-[4-(trifluoromethyl)phenyl]isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Chlorobenzyl)pyrrolidine oxalate | HCID 2735373 | — |
| Reactant | 4-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]- | HCID 68682921 | — |
| Product | 4-{[3-(2-Chlorobenzyl)pyrrolidin-1-yl]carbonyl}-5-[4-(trifluoromethyl)phenyl]isoxazole | HCID 59170022 | — |
Reaction Steps
The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and 3-(2-chlorobenzyl)pyrrolidine oxalate (17.1 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (9.2 mg). Calcd for C22H18ClF3N2O2: 434.1009, found 434.1000.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-1b76dbef514b4eac97321403c187a8c7 |
| Source note | uspto-grants-2010_02 |