5-Ethyl-2-methylpiperidine → 5-Ethyl-2-methyl-1-({5-[4-(trifluoromethyl)phenyl]isoxazol-4-yl}carbonyl)piperidine

HRID 1446256Notes

Reaction equation

HRID 1446256 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[CH:11][C:10]=2[C:14]([OH:16])=O)=[CH:5][CH:4]=1.[CH2:19]([CH:21]1[CH2:26][NH:25][CH:24]([CH3:27])[CH2:23][CH2:22]1)[CH3:20]>>[CH2:19]([CH:21]1[CH2:26][N:25]([C:14]([C:10]2[CH:11]=[N:12][O:13][C:9]=2[C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:18])[F:17])=[CH:8][CH:7]=2)=[O:16])[CH:24]([CH3:27])[CH2:23][CH2:22]1)[CH3:20]

Participants

3

Reactant 2

HCID 77275-Ethyl-2-methylpiperidineHCID 686829214-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 591700925-Ethyl-2-methyl-1-({5-[4-(trifluoromethyl)phenyl]isoxazol-4-yl}carbonyl)piperidine

Procedure

The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and 5-ethyl-2-methylpiperidine (7.6 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (5.3 mg). Calcd for C19H21F3N2O2: 366.1555, found 366.1552.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-3e3e3c6a1b1b4ae6b58b774ce27361cd
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

Loading…