HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Pyrrolidin-3-yl)pyridine--hydrogen chloride (1/1) → 4-[1-({5-[4-(Trifluoromethyl)phenyl] isoxazol-4-yl}carbonyl)pyrrolidin-3-yl]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Pyrrolidin-3-yl)pyridine--hydrogen chloride (1/1) | HCID 17749757 | — |
| Reactant | 4-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]- | HCID 68682921 | — |
| Product | 4-[1-({5-[4-(Trifluoromethyl)phenyl] isoxazol-4-yl}carbonyl)pyrrolidin-3-yl]pyridine | HCID 59170077 | — |
Reaction Steps
The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and 4-pyrrolidin-3-ylpyridine hydrochloride (11.1 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (11.6 mg). Calcd for C20H16F3N3O2: 387.1195, found 387.1193.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07666888B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-67817f769d4044a7b2fcf8a6fbd81352 |
| Source note | uspto-grants-2010_02 |