3,5-Dimethylpiperidine → HCID 59170055, compound

HRID 1446261Notes

Reaction equation

HRID 1446261 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[CH:11][C:10]=2[C:14]([OH:16])=O)=[CH:5][CH:4]=1.[CH3:19][CH:20]1[CH2:25][CH:24]([CH3:26])[CH2:23][NH:22][CH2:21]1>>[CH3:19][CH:20]1[CH2:25][CH:24]([CH3:26])[CH2:23][N:22]([C:14]([C:10]2[CH:11]=[N:12][O:13][C:9]=2[C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:18])[F:17])=[CH:8][CH:7]=2)=[O:16])[CH2:21]1

Participants

3

Reactant 2

HCID 1182593,5-DimethylpiperidineHCID 686829214-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 59170055HCID 59170055, compound

Procedure

The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and 3,5-dimethylpiperidine (6.8 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (2.2 mg). Calcd for C18H19F3N2O2: 352.1399, found 352.1399.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-8135e7b454184cf4bae0d61c0a6564ad
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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