N-Ethylbenzylamine → HCID 59170107, compound

HRID 1446262Notes

Reaction equation

HRID 1446262 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][N:12]=[CH:11][C:10]=2[C:14]([OH:16])=O)=[CH:5][CH:4]=1.[CH2:19]([NH:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH3:20]>>[CH2:22]([N:21]([CH2:19][CH3:20])[C:14]([C:10]1[CH:11]=[N:12][O:13][C:9]=1[C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:18])[F:17])=[CH:8][CH:7]=1)=[O:16])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 84352N-EthylbenzylamineHCID 686829214-Isoxazolecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-

Product 1

HCID 59170107HCID 59170107, compound

Procedure

The title compound was prepared from 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylic acid (12.9 mg, 0.050 mmol) and N-ethylbenzylamine (8.1 mg, 0.060 mmol) as described in synthetic method C and thereafter purified by preparative HPLC method B to give a solid (10.7 mg). Calcd for C20H17F3N2O2: 374.1242, found 374.1243.

Workup

  1. custompurified by preparative HPLC method B

Sources & evidence

ORD record
ord-5058bf0270924169a88187b6f27c146e
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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