Isoindoline → HCID 59170128, compound

HRID 1446328Notes

Reaction equation

HRID 1446328 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13](Cl)=[O:14])=[CH:4][CH:3]=1.[CH2:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][NH:17]1>ClCCl>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:17]2[CH2:18][C:19]3[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:16]2)=[O:14])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 422478IsoindolineHCID 729429065-(P-tolyl)isoxazole-4-carbonyl chloride

Product 1

HCID 59170128HCID 59170128, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 5-(4-methylphenyl)isoxazole-4-carbonyl chloride (10 mg, 0.045 mmol) in dichloromethane (1 mL) was added isoindoline (5.9 mg, 0.050 mmol, 1.1 eq.), and the reaction mixture was stirred for 1 h. The solvent was removed, and the residue was purified by preparative reverse-phase HPLC to give the title compound. HRMS (ESI, pos. ion) m/z calcd for C19H16N2O2: 304.1212, found 304.1222.

Workup

  1. customThe solvent was removed
  2. customthe residue was purified by preparative reverse-phase HPLC

Sources & evidence

ORD record
ord-2131cffe451e4d8bbd76f041d2f2b87c
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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