4-Benzyl-4-piperidinol → 4-Benzyl-1-{[5-(4-methylphenyl)isoxazol-4-yl]carbonyl}piperidin-4-ol

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Reaction Steps

To 5-(4-methylphenyl)isoxazole-4-carbonyl chloride (10 mg, 0.045 mmol) in dichloromethane (1 mL) was added 4-benzylpiperidin-4-ol (9.5 mg, 0.050 mmol, 1.1 eq.), and the reaction mixture was stirred for 1 h. The solvent was removed, and the residue was purified by preparative reverse-phase HPLC to give the title compound. HRMS (ESI, pos. ion) m/z calcd for C23H24N2O3: 376.1787, found 376.1790.

Provenance & Evidence