HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1446344Generated: November 2, 2026
Pyridine → 1-{[5-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl}-5-methyl-3-phenylpyrrolidin-3-ol
https://huagongshe.com/reaction/1446344
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 5-Methyl-3-phenyl-pyrrolidin-3-ol | HCID 3051395 | — |
| Reactant | 3-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid | HCID 3465472 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-{[5-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl}-5-methyl-3-phenylpyrrolidin-3-ol | HCID 59170159 | 20.5% |
Reaction Steps
Pyridine (13 μL, 0.16 mmol, 4 equ.) was added to a solution of 5-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid (8 mg, 0.04 mmol), 5-methyl-3-phenylpyrrolidin-3-ol (7 mg, 0.04 mmol) and TBTU (15 mg, 0.048 mmol, 1.2 equ.) in DMF (0.3 mL) at rt. The reaction mixture was stirred at 60° C. overnight. The crude product was purified by RP-HPLC. After evaporation of the solvents the product was dried in vacuum to yield the title compound (3 mg). MS (ESI, pos. ion) m/z: calcd for C21H20FN3O2: 365.1540, found 365.1541.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07666888B2 |
|---|
| Source dataset | uspto-grants-2010_02 |
|---|
| ORD ID | ord-f7220aeeddea4bdaa05c08db8d04df47 |
|---|
| Source note | uspto-grants-2010_02 |
|---|
