HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,2,3,4-Tetrahydro-2-naphthoic acid → 2-Methyl-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,2,3,4-Tetrahydro-2-naphthoic acid | HCID 101370 | — |
| Edukt | Potassium bis(trimethylsilyl)amide | HCID 3251421 | — |
| Edukt | 2,3-Dihydrofuran-2-carboxylic acid | HCID 20277547 | — |
| Edukt | Potassium tert-butoxide | HCID 23665647 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-Methyl-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid | HCID 12562882 | — |
Reaktionsschritte
The title compound was prepared following the procedures described for Reference Example 5 substituting 2,3-dihydrofuran-2-carboxylic acid with 1,2,3,4-tetrahydro-2-naphthoic acid at Step A and potassium tert-butoxide in tetrahydrofuran with potassium hexamethyldisilazide (0.5 M in toluene) at Step B. 1H NMR (500 MHz, CD3OD): δ 7.12-7.0 (m, 4H), 3.71 (d, 1H), 3.22 (d, 1H), 2.84 (t, 1H), 2.65 (d, 1H), 2.17 (m, 1H), 1.77 (m, 1H), 1.28 (s, 3H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07667053B2 |
| Quelldatensatz | uspto-grants-2010_02 |
| ORD ID | ord-4da4126bfeb5450d9e3874d076c46ab9 |
| Quellennotiz | uspto-grants-2010_02 |