HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-1-benzopyran-2-carboxylic acid → 2-methyl-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-1-benzopyran-2-carboxylic acid | HCID 2723665 | — |
| Reactant | Potassium bis(trimethylsilyl)amide | HCID 3251421 | — |
| Reactant | 2,3-Dihydrofuran-2-carboxylic acid | HCID 20277547 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-methyl-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid | HCID 21951714 | — |
Reaction Steps
The title compound was prepared following the procedures described for Reference Example 5 substituting 2,3-dihydrofuran-2-carboxylic acid with chromane-2-carboxylic acid at Step A and potassium tert-butoxide in tetrahydrofuran with potassium hexamethyldisilazide (0.5 M in toluene) at Step B. 1H NMR (500 MHz, CD3OD): δ 7.07 (t, 1H), 7.03 (d, 1H), 6.82 (m, 2H), 2.75 (m, 2H), 2.40 (m, 1H), 1.80 (m, 1H), 1.60 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07667053B2 |
| Source dataset | uspto-grants-2010_02 |
| ORD ID | ord-da54bf7e5d6749fe97e2a52ac5addac8 |
| Source note | uspto-grants-2010_02 |