2,3-Bis(4-chlorophenyl)-1-methylpropylamine hydrochloride → HCID 10025900, compound

HRID 1446425Notes

Reaction equation

HRID 1446425 reaction equation
Cl.Cl[C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH:10]([NH2:12])[CH3:11])=[CH:5][CH:4]=1.Cl.ClC1C=CC(C[C@@H](C2C=CC=CC=2)[C@@H](N)C)=CC=1.[CH3:40][C:41]1([C:51](O)=[O:52])[CH2:50][C:49]2[C:44](=[CH:45][CH:46]=[CH:47][CH:48]=2)[O:43][CH2:42]1>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][C@@H:9]([C:6]2[CH:7]=[CH:8][CH:3]=[CH:4][CH:5]=2)[C@@H:10]([NH:12][C:51]([C:41]2([CH3:40])[CH2:50][C:49]3[C:44](=[CH:45][CH:46]=[CH:47][CH:48]=3)[O:43][CH2:42]2)=[O:52])[CH3:11])=[CH:15][CH:16]=1

Participants

4

Reactant 3

HCID 222704272,3-Bis(4-chlorophenyl)-1-methylpropylamine hydrochlorideHCID 23404723HCID 23404723, compoundHCID 591711073,4-Dihydro-3-methyl-2H-1-benzopyran-3-carboxylic acid

Product 1

HCID 10025900HCID 10025900, compound

Procedure

The title compounds were prepared as a 1:1 mixture of diastereomers following the procedures described for Examples 5 and 6 substituting 2-amino-3,4-bis(4-chlorophenyl)butane hydrochloride salt (Reference Example 1) with N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-amine hydrochloride (Reference Example 3) and substituting 1,2,3,4-tetrahydro-2-naphthoic acid with 3-methylchromane-3-carboxylic acid (Reference Example 9). LC-MS: m/e 434 (M+H)+ (4.06 min).

Workup

  1. customm/e 434 (M+H)+ (4.06 min)

Sources & evidence

ORD record
ord-e7fde2d4ba1246ae8171832147e56ba1
Source dataset
uspto-grants-2010_02
Patent number
US07667053B2

Reaction notes

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