Tert-butyl 7-amino-4,5-dihydro-1H-benzo[D]azepine-3(2H)-carboxylate → 7-[8-(2-Methoxymethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amino]-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylic acid tert-butyl ester

HRID 144656Notes

Reaction equation

HRID 144656 reaction equation
[C:20]([CH3:21])([CH3:22])([CH3:23])[O:24][C:25](=[O:26])[N:27]1[CH2:28][CH2:29][c:30]2[c:31]([cH:34][cH:35][c:36]([NH2:38])[cH:37]2)[CH2:32][CH2:33]1.[Cl:1][c:2]1[n:3][n:4]2[c:5]([c:6](-[c:10]3[c:11]([CH2:16][O:17][CH3:18])[cH:12][cH:13][cH:14][cH:15]3)[cH:7][cH:8][cH:9]2)[n:19]1>>[c:2]1([NH:38][c:36]2[cH:35][cH:34][c:31]3[c:30]([cH:37]2)[CH2:29][CH2:28][N:27]([C:25]([O:24][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:26])[CH2:33][CH2:32]3)[n:3][n:4]2[c:5]([c:6](-[c:10]3[c:11]([CH2:16][O:17][CH3:18])[cH:12][cH:13][cH:14][cH:15]3)[cH:7][cH:8][cH:9]2)[n:19]1

Participants

3

Reactant 2

HCID 11402789Tert-butyl 7-amino-4,5-dihydro-1H-benzo[D]azepine-3(2H)-carboxylateHCID 674814042-chloro-8-(2-Methoxymethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine

Product 1

HCID 498382737-[8-(2-Methoxymethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amino]-1,2,4,5-tetrahydro-3-benzazepine-3-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-bd5e197bbf854a74851c59f308661f15
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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