HCID 86602489, compound → 1-(2-Methylphenyl)ethan-1-amine

HRID 1446573Notes

Reaction equation

HRID 1446573 reaction equation
[N:1]([CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:12])[CH3:5])=[N+]=[N-].[H][H]>CO.[C].[Pd]>[C:7]1([CH3:12])[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[CH:4]([NH2:1])[CH3:5]

Participants

5

Reactant 2

HCID 86602489HCID 86602489, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 33910421-(2-Methylphenyl)ethan-1-amineYield 77.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

10% palladium-carbon (water content: 50%, 50 mg) was added to a solution of 1-(1-azidoethyl)-2-methylbenzene (744 mg) in methanol (5 mL), and the reaction solution was stirred in a hydrogen atmosphere at room temperature for 1 hour. The reaction solution was filtered on a celite, and the filtrate was concentrated under reduced pressure to obtain 482 mg of the title compound. The physical properties of the compound are as follows.

Workup

  1. filtrationThe reaction solution was filtered on a celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8ec7cbf20d844b489e280acdd260e112
Source dataset
uspto-grants-2010_02
Patent number
US07667041B2

Reaction notes

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