7-Chloro-3-iodoimidazo[1,2-a]pyridine → HCID 68542885, compound

HRID 1446678Notes

Reaction equation

HRID 1446678 reaction equation
I[C:2]1[N:6]2[CH:7]=[CH:8][C:9]([Cl:11])=[CH:10][C:5]2=[N:4][CH:3]=1.CC1(C)C(C)(C)OB([C:20]2[CH:25]=[CH:24][C:23]([CH2:26][C:27]([NH:29][C:30]3[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:39])([F:38])[F:37])[CH:31]=3)=[O:28])=[CH:22][CH:21]=2)O1>>[Cl:11][C:9]1[CH:8]=[CH:7][N:6]2[C:2]([C:20]3[CH:21]=[CH:22][C:23]([CH2:26][C:27]([NH:29][C:30]4[CH:35]=[CH:34][CH:33]=[C:32]([C:36]([F:37])([F:38])[F:39])[CH:31]=4)=[O:28])=[CH:24][CH:25]=3)=[CH:3][N:4]=[C:5]2[CH:10]=1

Participants

3

Reactant 2

HCID 574976977-Chloro-3-iodoimidazo[1,2-a]pyridineHCID 68541689HCID 68541689, compound

Product 1

HCID 68542885HCID 68542885, compound

Procedure

Couple 3-iodo-7-chloro-imidazo[1,2,a]pyridine (655 mg, 2.35 mmol) and 2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-N-(3-trifluoromethyl-phenyl)-acetamide (1.00 g, 2.47 mmol) using a procedure similar to Preparation 99B. MS(ES), m/z 430 (M+1).

Sources & evidence

ORD record
ord-b32722ee48174c5d8956b673772344b7
Source dataset
uspto-grants-2010_02
Patent number
US07666879B2

Reaction notes

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