Chloride → HCID 68548133, compound

Participants

Reaction Steps

Combine (4-bromo-2-fluoro-phenyl)-acetic acid (3.81 g, 16.35 mmol) and 5-(1-Methyl-cyclopropyl)-[1,3,4]thiadiazol-2-ylamine (2.54 g, 16.35 mmol) in THF (45 mL). Under N2, add 4-methyl-morpholine (2.16 mL, 19.62 mmol), then 4-(4,6-dimethoxy-[1,3,5]triazin-2-yl)-4-methyl-morpholin-4-ium; chloride (5.43 g, 19.62 mmol). Stir the reaction mixture for 14 hours under N2. Extract with ethyl acetate versus water. Wash with aqueous saturated sodium chloride, dry over magnesium sulfate, filter, and concentrate. Triturate the resulting solid from ethyl acetate/hexanes, filter, and dry to give fluffy white solid as the title compound (2.86 g, 47%). MS (ES), mm/z 370, 372 (M+1).

Provenance & Evidence