(4-Boc-piperazin-1-yl)-(3-nitro-5-trifluoromethyl-phenyl)-methanone → HCID 21959496, compound

Participants

Reaction Steps

Hydrogentate 4-(3-nitro-5-trifluoromethyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (4.8 g, 11.9 mmol) in MeOH (120 mL) with 10% Pd on activated carbon (400 mg) at room temperature for 3 hours. Filter and concentrate into a white solid as the title compound (3.94 g, 10.55 mmol, 89%). MS (ES), m/z 372 (M−1). Use in the next step without purification.

Provenance & Evidence