7-Pyridin-4-yl-imidazo[1,2-a]pyridine → HCID 68543160, compound

HRID 1446723Notes

Reaction equation

HRID 1446723 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[C:4]([F:16])[CH:3]=1.[N:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][N:26]3[CH:29]=[CH:30][N:31]=[C:25]3[CH:24]=2)=[CH:19][CH:18]=1>>[C:12]([O:11][C:9](=[O:10])[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([C:29]2[N:26]3[CH:27]=[CH:28][C:23]([C:20]4[CH:21]=[CH:22][N:17]=[CH:18][CH:19]=4)=[CH:24][C:25]3=[N:31][CH:30]=2)=[CH:3][C:4]=1[F:16])([CH3:15])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 685456367-Pyridin-4-yl-imidazo[1,2-a]pyridineHCID 70650712HCID 70650712, compound

Product 1

HCID 68543160HCID 68543160, compound

Procedure

Couple 4-bromo-2-fluoro-phenylacetic acid, tert-butyl ester (3.65 g, 18.68 mmol) with 7-pyridin-4-yl-imidazo[1,2-a]pyridine (5.40 g, 18.68 mmol) as described in Preparation 153. MS(ES), m/z 404 (M+1).

Sources & evidence

ORD record
ord-9f3b5511e0ea4d00bdde7f11eba8ca6d
Source dataset
uspto-grants-2010_02
Patent number
US07666879B2

Reaction notes

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