Diisopropylethylamine → HCID 57863462, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 4-(7-thien-3-yl-imidazo[1,2-a]pyridin-3-yl)-benzylamine (0.058 g, 0.19 mmol), (5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-carbamic acid 2,2,2-trichloro-ethyl ester (0.093 g, 0.23 mmol) and diisopropylethylamine (0.071 g, 0.55 mmol) in DMSO (3.6 mL). Heat the mixture at 62° C. for 8 hours. After evaporation of solvent, dilute the reaction with water and ethyl acetate. Extract the water phase with ethyl acetate and wash the combined organic layers with saturated aqueous saturated sodium chloride and evaporate to dryness. Purify the residue by silica gel column chromatography (dichlromethane/ethyl acetate gradient) to give 0.023 g (21% yield) of desired compound: MS(ES), m/z 561 (M+1).

Provenance & Evidence