Potassium Carbonate → HCID 68546393, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve {4-[7-(6-fluoro-pyridin-3-yl)-imidazo[1,2-a]pyridin-3-yl]-benzyl}-carbamic acid tert-butyl ester (0.500 g, 1.19 mmol, 1.0 eq.) and N-methyl piperazine (0.53 mL, 4.78 mmol, 4.0 eq.) in DMSO (20 mL). Add K2CO3 (0.330 g, 2.0 eq.). Stir the reaction mixture at 80° C. overnight. Pour the mixture into 20 mL of ice. Filter the solid, and purify by silica gel chromatography with a 0-5% MeOH/DCM gradient to give the title compound 0.408 g (0.82 mmol, 70%) as a slightly yellow solid. Use the solid directly in the reaction B below: MS(ES), m/z 499 (M+1).

Provenance & Evidence