Piperazine → HCID 57863429, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 1-{4-[7-(6-Morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-a]pyridin-3-yl]-benzyl}-3-(3-trifluoromethyl-phenyl)-urea (0.220 g, 0.435 mmol, 1.0 eq.) in DMSO (2 mL). Add K2CO3 (0.120 g, 0.870 mmol, 2.0 eq.). Add piperazine (0.150 g, 1.74 mmol, 4.0 eq.). Stir the reaction mixture at 80° C. overnight under nitrogen. Pour the reaction mixture into 40 mL of ice and filter. Purify the yellow solid by silica gel chromatography using a 0-5% MeOH/DCM gradient to give the title compound 0.170 g (0.33 mmol, 76%) as a slightly yellow solid: MS(ES), m/z 518 (M+1).

Provenance & Evidence