Hydrochloric Acid → HCID 57863466, compound

Participants

Reaction Steps

Dissolve 4-(3-{2-[2-fluoro-4-(7-pyridin-2-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-acetylamino}-5-trifluoromethyl-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (0.76 g, 0.108 mmol) in 1:1 CH2Cl2 MeOH (20 mL) and add 2M HCl in THF (2 mL), then stir 2 hours and concentrate in vacuo. Load onto a Varian MegaElut® SCX cartridge (10 gram cartridge prewashed with methanol), rinse with methanol to remove impurities then elute crude product with 2 M NH3 in methanol. Concentrate this solution in vacuo then purify by silica gel chromatography (0%→10% 2 M NH3 Methanol:DCM) to give a yellow residue (0.400 g, 49% over 2 steps). MS (ES), m/z 603 (M+1).

Provenance & Evidence