Ammonium formate → HCID 57863442, compound

Participants

Reaction Steps

Suspend 2-[2-nitro-4-(7-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-N-(4-trifluoromethyl-pyridin-2-yl)-acetamide (0.18 g, 0.35 mmol) and ammonium formate (0.11 g, 1.82 mmol) in anhydrous methanol (5 mL) and bubble nitrogen through the solution for 5 minutes. Under a positive stream of nitrogen, add 10% Pd-on carbon (0.03, 0.03 mmol) to the solution and stir the reaction at ambient temperature for 18 hours. Filter the reaction contents through a pad of Celite® and wash the pad with methanol (40 mL). Concentrate the solution and then chromatograph the residue on silica using a gradient of (0→2→5%) methanol in dichloromethane to yield the title compound (0.03 g, 0.05 mmol). MS(ES), m/z 489 (M+1).

Provenance & Evidence