HCID 68543069, compound → HCID 68542292, compound

Participants

Reaction Steps

Couple N-(5-tert-Butyl-isoxazol-3-yl)-2-[4-(7-chloro-imidazo[1,2-a]pyridin-3-yl)-phenyl]-acetamide (0.700 g, 1.71 mmol) to {2-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzenesulfonyl]-ethyl}-carbamic acid tert-butyl ester (0.775 g, 1.88 mmol) using procedure similar to Example 115. Treat the crude extracts to SCX ion exchange chromatography during which time some of the BOC-group is cleaved. Elute from the SCX column and treat with 2N HCl in dioxane (125 mL) and 10 mL of methanol for 2 hours. Evaporate in vacuo to provide the intermediate (0.87 g, 1.38 mmol). MS(ES), m/z 616 (M+1).

Provenance & Evidence