Methanol → HCID 57863446, compound

Participants

Reaction Conditions

Reaction Steps

Add Lawesson's reagent (0.246 g, 0.61 mmol, 1.2 eq.) to the solution of 2-[4-(7-pyridin-4-yl-imidazo[1,2-a]pyridin-3-yl)-phenyl]-N-(3-trifluoromethyl-phenyl)-acetamide (0.240 g, 0.51 mmol, 1.0 eq.) in hexamethylphosphoramide (2.5 mL). Stir the reaction mixture at 80° C. overnight. Cool the mixture down to room temperature and load onto a Varian MegaElut® SCX cartridge (5 gram cartridge prewashed with methanol). Rinse with methanol to remove impurities then elute crude product with 2 M NH3 in methanol. Concentrate this solution in vacuo then purify HPLC to give a yellow foam (0.078 g, 31%). MS (ES), m/z 489 (M+1).

Provenance & Evidence