Isocyanatocyclopropane → HCID 12803460, compound

HRID 1446774Notes

Reaction equation

HRID 1446774 reaction equation
[CH:1]1([N:4]=[C:5]=[O:6])[CH2:3][CH2:2]1.[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][CH:15]=[O:16]>>[CH:1]1([NH:4][C:5](=[O:6])[N:14]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[F:7])[CH:15]=[O:16])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 637659IsocyanatocyclopropaneHCID 12803459N-(2-Fluorophenyl)formamide

Product 1

HCID 12803460HCID 12803460, compound

Conditions

Temperature
100 °C

Procedure

An equimolar mixture of 1A and 1B in tetrohydrofuran was stirred for 2 days at 100° C. The solvent was evaporated, and the residue was recrystallized from ether to give 1, as a white solid, m.p.: 104°-105° C.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was recrystallized from ether
  3. customto give 1

Sources & evidence

ORD record
ord-5376252102a0497e95dc9ef1c1ca7136
Source dataset
uspto-grants-1982_02
Patent number
US04313755

Reaction notes

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