Acetic Anhydride → N-(2-Fluorophenyl)acetamide

HRID 1446778Notes

Reaction equation

HRID 1446778 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=1[NH2:11]>C(O)(=O)C>[F:8][C:9]1[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=1[NH:11][C:5](=[O:7])[CH3:6]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 95842-Fluoroaniline

Product 1

HCID 67860N-(2-Fluorophenyl)acetamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

25 ml of acetic anhydride was added to a mixture of 11.1 g of 2-fluoroaniline and 25 ml of glacial acetic acid. The mixture was heated at reflux for 5 minutes, then diluted with ice water. The resulting mixture was filtered, and the solid was dried to give N-(2-fluorophenyl)acetamide (3A), as a white solid, m.p.: 76°-77° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 5 minutes
  3. filtrationThe resulting mixture was filtered
  4. customthe solid was dried

Sources & evidence

ORD record
ord-4244ebe38bb743e08d6a1203a3616166
Source dataset
uspto-grants-1982_02
Patent number
US04313755

Reaction notes

Loading…