HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1446779Generated: October 31, 2026
N-(2-Fluorophenyl)acetamide → N-[(Cyclopropylamino)carbonyl]-N-(2-fluorophenyl)acetamide
https://huagongshe.com/reaction/1446779
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-(2-Fluorophenyl)acetamide | HCID 67860 | — |
| Reactant | Isocyanatocyclopropane | HCID 637659 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[(Cyclopropylamino)carbonyl]-N-(2-fluorophenyl)acetamide | HCID 12803463 | — |
Reaction Steps
A mixture of 5.8 g of 3A, 50 ml of tetrahydrofuran and 5.0 g of 1A was heated in a sealed glass cylinder for 12 hours at 100° C. Then the solvent was evaporated, and the residue was recrystallized from ether/hexane to give 3, as a white solid, m.p.: 43°-45° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04313755 |
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| Source dataset | uspto-grants-1982_02 |
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| ORD ID | ord-5f971edabde5429c91b99d46cfbaa9f9 |
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| Source note | uspto-grants-1982_02 |
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