HCID 12831592, compound → HCID 12831593, compound

Participants

Reaction Steps

A solution of 7.0 g of 1-[2-(phenylmethyl)phenyl]-4-dimethylaminocyclohexanol of Example 1 in 30 ml of acetic acid and 3 ml of hydrochloric acid (concentrated) is heated to reflux for 41/2 hours. After the contents are allowed to stand at 5° C. for 3 days, the solvent is evaporated off and the residue is dissolved in 50 ml of water. The solution is filtered and made alkaline with a slight excess of 50% aqueous NaOH. After cooling, the product is collected by suction filtration, and the filter cake is washed with water and dried in vacuo over P2O5 at 40° C. to yield 6.57 g (99.7% yield) of 1-[2-(phenylmethyl)phenyl]-4-dimethylaminocyclohex-1-ene m.p. 44°-45° C.

Provenance & Evidence