HCID 12833672, compound → HCID 20271761, compound

HRID 1446841Notes

Reaction equation

HRID 1446841 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:13]([CH:14]([CH3:16])[CH3:15])[C:12](SC)=[N:11][CH:10]=2)=[CH:5][CH:4]=1>[Ni].C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:13]([CH:14]([CH3:16])[CH3:15])[CH:12]=[N:11][CH:10]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 12833672HCID 12833672, compound

Product 1

HCID 20271761HCID 20271761, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of 7.5 parts of 5-(4-methoxyphenyl)-1-(1-methylethyl)-2-(methylthio)-1H-imidazole, 10 parts of Raney-nickel catalyst and 80 parts of ethanol is stirred and refluxed for 2h. The catalyst is filtered off and another 10 parts of Raney-nickel catalyst is added. The whole is stirred for 2 hours at reflux temperature. The Raney-nickel catalyst is filtered off and the filtrate is evaporated, yielding 4 pants of 5-(4-methoxyphenyl)-1-(1-methylethyl)-1H-imidazole as a solid residue.

Workup

  1. temperaturerefluxed for 2h
  2. filtrationThe catalyst is filtered off
  3. additionanother 10 parts of Raney-nickel catalyst is added
  4. stirringThe whole is stirred for 2 hours
  5. temperatureat reflux temperature
  6. filtrationThe Raney-nickel catalyst is filtered off
  7. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-4b5a3ce7c0f74e989f66ea288d67c965
Source dataset
uspto-grants-1982_02
Patent number
US04313953

Reaction notes

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