反应详情

A mixture of 2-{4-[N-methyl-N-(5-chloro-2-benzoxazolyl)amino]phenoxy}propionic acid (3.0 g, 0.0087 mole; see Example 9), thionyl chloride (0.76 ml, 0.01 mole) and chloroform (25 ml) was heated under reflux for a period of 3 hours. The reaction mixture was cooled and the solvent and excess thionyl chloride was removed by distillation under reduced pressure to give the title compound.

1. temperaturewas heated
2. temperatureunder reflux for a period of 3 hours
3. temperatureThe reaction mixture was cooled
4. customthe solvent and excess thionyl chloride was removed by distillation under reduced pressure