1,1'-(Diazomethylene)bis(benzene) → HCID 54207516, compound

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Reaction Steps

A solution of approximately 214 g of diphenyldiazomethane in 1 l of methylene chloride is added dropwise at 22°, while cooling, to a solution of 236.7 g of the resulting crude (2R)-BOC-serine in 700 ml of methylene chloride and the mixture is stirred for 11/2 hours at 20°. The mixture is concentrated by evaporation in vacuo, the residue is taken up in ethyl acetate and washed at 0° with a phosphate buffer of a pH of 2.0 then of a pH of 7.0. The dried organic phase yields a crystalline residue on concentration by evaporation which is digested in hexane and, after filtering, (2R)-N-BOC-serine diphenylmethyl ester is obtained; m.p. 116°-117° (corrected).

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