Hydrogen Bromide → 7-Hydroxy Ropinirole HBr

Participants

Reaction Steps

A 0.284 g (0.765 mmole) portion of 4-(2-di-n-propylaminoethyl)-7-methoxy-2(3H)-indolone hydrobromide was placed in a flask and approximately 5 ml of constant boiling hydrobromic acid was distilled (from stannous chloride) directly into the flask. The resulting mixture was stirred at reflux under an argon atmosphere for 3 hours. Evaporation of the solvents produced a solid residue which was recrystallized twice from methanol-ethyl acetate to provide 0.206 g (75%) of 4-(2-di-n-propylaminoethyl)-7-hydroxy-2(3H)-indolone hydrobromide. m.p. 252°-254°.

Provenance & Evidence