HCID 178512609, compound → HCID 178503901, compound

HRID 1446986Notes

Reaction equation

HRID 1446986 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][NH2:17])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]>C(O)C>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][NH:17][C:5](=[N:1][C:2]#[N:3])[S:6][CH3:7])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

3

Reactant 1

HCID 178512609HCID 178512609, compound

Product 1

HCID 178503901HCID 178503901, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-guanidino-4-(3-aminomethylphenyl)thiazole (0.5 g.) in warm ethanol (10 ml.) was added dimethyl (cyanoimido)dithiocarbonate (0.3 g.). The mixture was stirred for 1 hour during which time a precipitate gradually formed. This precipitate was filtered off to give 2-guanidino-4-[3-(3-cyano-2-methylisothioureidomethyl)phenyl]thiazole.

Workup

  1. customgradually formed
  2. filtrationThis precipitate was filtered off

Sources & evidence

ORD record
ord-1b171e0b600e4541a2614239bd7be5c4
Source dataset
uspto-grants-1982_02
Patent number
US04315009

Reaction notes

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