Acetic Anhydride → HCID 178474130, compound

HRID 1446987Notes

Reaction equation

HRID 1446987 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3].[C:17]([O:20][C:21](=[O:23])[CH3:22])(=[O:19])[CH3:18]>C(O)(=O)C>[C:17]([OH:20])(=[O:19])[CH3:18].[C:17]([OH:20])(=[O:19])[CH3:18].[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][C:21](=[O:23])[CH3:22])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1785126111-(4-(3-Aminophenyl)thiazol-2-yl)guanidine

Product 1

HCID 178474130HCID 178474130, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 2-guanidino-4-(3-aminophenyl)thiazole (0.24 g.) in acetic acid (5 ml.) was added acetic anhydride (0.25 g.). The mixture was allowed to stand for 18 hours and the white solid precipitate (0.25 g.) was filtered off to give 2-guanidino-4-(3-acetylaminophenyl)thiazole diacetate, m.p. 171°-173° C., solidifies and remelts at 258°-261° C.

Workup

  1. filtrationthe white solid precipitate (0.25 g.) was filtered off

Sources & evidence

ORD record
ord-eb203c49d3bd487fbd9aca5c2d9219fe
Source dataset
uspto-grants-1982_02
Patent number
US04315009

Reaction notes

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