5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 178483230, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-[3-(2-guanidinothiazol-4-yl)phenylamino]-1-methylthio-2-nitroethylene (0.16 g.) and 2-[(5-dimethylaminomethylfuran-2-yl)methylthio]ethylamine (1 g.) was heated at 100° C. for 2 hours. The product was extracted 10 times with 5 ml. portions of diethyl ether and the residual gum was applied to Merck 60 F254 preparative plates and eluted with ethyl acetate/methanol/concentrated aqueous ammonia 6:1:1 v/v/v. The solid obtained (0.05 g.) was crystallised twice from acetonitrile to give 1-[3-(2-guanidinothiazol-4-yl)phenylamino]-1-[2-[(5-dimethylaminomethylfuran-2-yl)methylthio]ethylamino]-2-nitroethylene, m.p. 175°-180° C. (decomp.).

Provenance & Evidence