反应详情

A mixture of 1.00 g. (3.53 mmoles) of 5-bromo-tryptamine-2-carboxylic acid and 80 ml. of 10% aqueous sulfuric acid is stirred and refluxed for 30 hours. The pH of the mixture is adjusted to 9 with concentrated aqueous ammonia under cooling in an ice bath, and the alkaline mixture is extracted with 4×20 ml. of chloroform. The organic extracts are combined, washed with 5% aqueous sodium hydroxide solution and then with water, dried over anhydrous magnesium sulfate, filtered, and the filtrate is evaporated in vacuo. 0.48 g. (58%) of 5-bromo-tryptamine are obtained as an oily residue.

1. additionA mixture of 1.00 g
2. temperaturerefluxed for 30 hours
3. temperatureunder cooling in an ice bath
4. extractionthe alkaline mixture is extracted with 4×20 ml
5. washwashed with 5% aqueous sodium hydroxide solution
6. dry with materialwith water, dried over anhydrous magnesium sulfate
7. filtrationfiltered
8. customthe filtrate is evaporated in vacuo