1-Methoxyethanol → HCID 22819077, compound

Participants

Reaction Steps

A mixture of 7.5 g of 6-amino-1-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-1,5-dihydro-4H-imidazo[4,5-c]-pyridin-4-one, 1.5 g of 20% palladium on carbon, 6.4 ml of acetic acid, and 150 ml of methoxy-ethanol is hydrogenated at 50° C. and ca 3 atmospheres until uptake of hydrogen ceases. The mixture is filtered, evaporated in vacuo, dissolved in water, and treated with 50 ml of wet IR-45 ion exchange resin. The filtrate is concentrated to dryness in vacuo and recrystallized from ethanol-water to provide 3.2 g of 6-amino-1-β-D-arabinofuranosyl-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one.

Provenance & Evidence