Ammonia → HCID 54030984, compound

Participants

Reaction Steps

A mixture of 6.0 g of 4-cyano-5-cyanomethyl-1-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)imidazole and 300 ml of dry methanol saturated at 0° C. with ammonia is kept in a steel bomb at ambient temperatures for 24 hours and then evaporated in vacuo to dryness. The residue is triturated with ether, dissolved in methanol, absorbed on silica gel, and chromatographed over silica gel with chloroform-methanol (10:1) to provide 4.0 g of 4,6-diamino-1-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)imidazo[4,5-c]pyridine.

Provenance & Evidence