1-Methoxyethanol → HCID 54265562, compound

Participants

Reaction Steps

A mixture of 5.0 g of 4,6-diamino-3-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-3H-imidazo[4,5-c]pyridine, 1.5 g of 20% palladium on carbon, 1.6 ml of acetic acid and 150 ml of methoxyethanol is hydrogenated at 50° C. and ca. 3 atmospheres until uptake of hydrogen ceases. The mixture is filtered, evaporated in vacuo, dissolved in water, and treated with 50 ml of wet IR-45 ion exchange resin. The filtrate is concentrated to dryness and recrystallized from ethanol-water to provide 2.0 g of 3-β-D-arabinofuranosyl-4,6-diamino-3H-imidazo-[4,5-c]pyridine.

Provenance & Evidence